Radiation-Induced Reversion of Transition Mutants

Studies with Purple Adenine Mutants in Neurospora Crassa. III. Reversion of X-Ray-Induced Mutants.

Reversion of aryl sulfataseless mutants of Neurospora.

I N previous publications from this laboratory, we have described two loci, called cys-3 and eth-lr, that control a family of enzymes of sulfur anabolism in Neurospora ( MARZLUF and METZENBERG 1968; METZENBERG 1968). These could be viewed as regulatory genes in search of a locus to control, since no proven structural mutants for any of the regulated enzymes were available. KERR and FLAVIN (1970...

Vaccine-induced T cells control reversion of AIDS virus immune escape mutants.

Many current-generation human immunodeficiency virus (HIV) vaccines induce specific T cells to control acute viremia, but their utility following infection with escape mutant virus is unclear. We studied reversion to wild type of an escape mutant simian-HIV in major histocompatibility complex-matched vaccinated pigtail macaques. High levels of vaccine-induced CD8+ T cells strongly correlated wi...

High-frequency reversion of geminivirus replication protein mutants during infection.

The geminivirus replication protein AL1 interacts with retinoblastoma-related protein (RBR), a key regulator of the plant division cell cycle, to induce conditions permissive for viral DNA replication. Previous studies of tomato golden mosaic virus (TGMV) AL1 showed that amino acid L148 in the conserved helix 4 motif is critical for RBR binding. In this work, we examined the effect of an L148V ...

Ultraviolet-induced reversion of cyc1 alleles in radiation-sensitive strains of yeast. I. rev1 Mutant strains.

The role of the REV3 gene function in UV-induced mutagensis in the yeast Saccharomyces cerevisiae has been examined by determining the reversion of 12 well-defined cyc1 mutations in diploid strains homozygous for the rev3--1 or rev3--3 allele. The 12 cyc1 alleles include one ochre, one amber, four initiation, two proline missense, and four frameshift mutations. We find that the rev3 mutations r...